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Amnios is a multi-directionally scrolling top down shoot 'em up set across ten levels, each representing a planet whose eco-system has been infected. The controls involved thrusting and rotating, similarly to Asteroids.
There are two ways to successfully complete the level - destroy enough of the infection to allow the planet to survive, or rescue enough of the citizens, Defender-style. For each of the organs to be destroyed, a specific weapon can be created to cleanse it easier - blueprints must be collected and taken back to your ship for this.